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Precision Medicine

HepB Typer-Precore

Detection of Precore Mutations in Hepatitis B Virus

Product Overview


In case of mutations in the precore and core promoter regions of the HBV gene, even though HBeAg have disappeared, HBV still proliferates to cause hepatitis. Therefore the chronic clinical outcome of HBeAg-negative hepatitis B may be worse compared to that of HBeAg-positive hepatitis.
HepB Typer-Precore detects mutations in the HBV precore region and provides the basis for the treatment.

Features

  • High Accuracy and Sensitivity
    - Analytical Sensitivity: 500 IU/ml
  • Detection of Wide Range Mutation
    - HBV Precore nt1613, nt1653, nt1753, nt1762, nt1764, nt1846, nt1896, nt1899
  • Definitive Determination of Mixture of Multiple Mutations
    - Precisely identifies mixture of multiple mutations, whereas direct sequencing could not identify specific genotypes with a double mutation in one codon due to the inability of sequencing to determine haplotype

Result Examples

  • #1 – Wild Type


  • #2 – Mutant Type


No. nt1613 nt1653 nt1753 nt1762 nt1764 nt1846 nt1896 nt1899
#1 G C T A G A G G Wild
#2 A T C T A T A A Mut

Compatible Instruments

  • MALDI-TOF MS
    (Bruker - Microflex)

Order Information

Product Cat. No. Size
HepB Typer-Precore GM1400 96 tests/kit

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