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Precision Medicine

HepB Typer-Lamivudine

Detection of Lamivudine Resistance in Chronic Hepatitis B

Product Overview

Chronic hepatitis B can progress to cirrhosis and hepatocellular carcinoma, and the inhibition of the proliferation of the causative hepatitis B virus is clinically important. As the duration of antiviral administration increases, the risk of drug resistance also increases, making long-term inhibition of hepatitis B viral load more difficult.
HepB Typer-Lamivudine provides a sensitive diagnosis of mutations that cause Lamivudine resistance and provides guidelines for the drug regimen of chronic hepatitis B treatment.

Features

  • High Accuracy and Sensitivity
    - Analytical sensitivity: 100 IU/ml
    - Fully concordant with direct or clonal sequencings
  • Early Detection of Drug Resistant Virus
    - Detects drug resistant virus of less than 10% of the whole viral population
  • Monitoring of Relative Abundance
    - Predicts viral breakthrough, the main cause for failure in hepatitis B treatment, by monitoring predominance of resistant virus known to precede viral breakthrough
  • Definitive Determination of Mixture of Multiple Mutations
    - Precisely identifies mixture of multiple mutations, whereas direct sequencing could not identify specific genotypes with a double mutation in one codon due to the inability of sequencing to determine haplotype
Antiviral agents HBV polymerase
rt180 rt181 rt184 rt194 rt202 rt204 rt236 rt250
Lamivudin(LMV)
Adefovir(ADV)
Entecavir(ETV)

Result Examples

  • #1 – Lamivudine resistance ( X )


  • #2 – Lamivudine resistance ( O )


No. HBV rt180 rt204
#1 + Leu Met Wild
#2 + Met Val Mutant

Compatible Instruments

  • MALDI-TOF MS
    (Bruker - Microflex)

Order Information

Product Cat. No. Size
HepB Typer-Lamivudine GM1000 96 tests/kit

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