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Precision Medicine

HepB Typer-Entecavir

Detection of Entecavir Resistance in Chronic Hepatitis B

Product Overview

Chronic hepatitis B can progress to cirrhosis and hepatocellular carcinoma, and the inhibition of the proliferation of the causative hepatitis B virus is clinically important. As the duration of antiviral administration increases, the risk of drug resistance also increases, making long-term inhibition of hepatitis B viral load more difficult.
HepB Typer-Entecavir provides a sensitive diagnosis of mutations that cause Entecavir resistance and provides guidelines for the drug regimen of chronic hepatitis B treatment.

Product highlights

  • High Accuracy and Sensitivity
    - Analytical sensitivity: 100 IU/ml
    - Fully concordant with direct or clonal sequencings
  • Early Detection of Drug Resistant Virus
    - Detects drug resistant virus of less than 10% of the whole viral population
  • Monitoring of Relative Abundance
    - Predicts viral breakthrough, the main cause for failure in hepatitis B treatment, by monitoring predominance of resistant virus known to precede viral breakthrough
  • Definitive Determination of Mixture of Multiple Mutations
    - Precisely identifies mixture of multiple mutations, whereas direct sequencing could not identify specific genotypes with a double mutation in one codon due to the inability of sequencing to determine haplotype
Antiviral agents HBV polymerase
rt180 rt181 rt184 rt194 rt202 rt204 rt236 rt250
Lamivudin(LMV)
Adefovir(ADV)
Entecavir(ETV)

Result Examples

  • # 1 - Entecavir Resistance (X)


  • # 2 - Entecavir Resistance (O)


No. HBV rt184 rt202 rt250
#1 + Thr Ser Met Wild
#2 + Phe Ser Met Mutant

Compatible Instruments

  • MALDI-TOF MS
    (Bruker - Microflex)

Order Information

Product Cat. No. Size
HepB Typer-Entecavir GM1300 96 tests/kit

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